Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment
نویسندگان
چکیده
منابع مشابه
Risk Assessment for Neurobehavioral Toxicity
Background: Brain activity has been investigated by several methods with different principles, notably optical ones. Each method may offer information on distinct physiological or pathological aspects of brain function. The ideal instrument to measure brain activity should include complementary techniques and integrate the resultant information. As a "low cost" approach towards this objective, ...
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A study by the National Academy of Sciences/National Research Council (NAS/NRC) found neurobehavioral toxicity to be one of the areas where almost no data are available for the assessment of toxicity. Using the NAS/NRC report and a data base from the American Conference of Government Industrial Hygienists (ACGIH), an estimate of the number of neurobehavioral toxins in commercial chemicals can b...
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Testing as a general trait of social life has received a great deal of attention by many language teachers and scholars. Throughout history, people have been tested to prove their abilities and experiences or to confirm their capacities. Many authorities have said that assessment and instruction should be integrated as a single and inseparable activity which seeks to understand development by a...
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Behavioral end points for neurotoxicity risk assessment have been developed and examined over the past three decades. They are now ready to move from simple qualitative guidelines, such as exemplified by reference doses, to more quantitative models, such as benchmark doses, based on dose-response information. Risk assessors, confronted by a wider array of methodologies and data than in the past...
متن کاملThe intersection of risk assessment and neurobehavioral toxicity.
Neurobehavioral toxicology is now established as a core discipline of the environmental health sciences. Despite its recognized scientific prowess, stemming from its deep roots in psychology and neuroscience and its acknowledged successes, it faces additional demands and challenges. The latter, in fact, are a product of its achievements because success at one level leads to new and higher expec...
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ژورنال
عنوان ژورنال: Frontiers in Toxicology
سال: 2021
ISSN: 2673-3080
DOI: 10.3389/ftox.2021.629229